BonoFill™

A personalized, viable bone graft

BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.

What makes BonoFill™ so unique?

bonofill img2a

Broad applicability to all indications and bone gap sizes

Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

Maxillofacial Bone Regeneration

Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.

Broad applicability to all indications and bone gap sizes

Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

Maxillofacial Bone Regeneration

Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.

Pre transplant, the patient’s average residual bone height was 6.6 mm

3 months following BonoFill^TM transplantation, average bone height was 14.8 mm

6 months following BonoFill^TM transplantation, bone height 15.8 mm, demonstrating new bone growth of 9.2 mm

BonoFill™ – Orthopedic Indication

Critical Bone Defect, Preliminary Results - BNS05

Pre-Transplant

5 cm long bone gap
3 previous treatment failures
Limited weight bearing ability
Constant pain

12 Months Post Transplant

Complete healing and gap closure
No pain
Normal function & weight bearing
No adverse events

Full load-bearing capacity 2.5 months after BonoFill™ transplantation

BonoFill™ – Orthopedic Indication

Critical Bone Defect, Preliminary Results - BNS05

Pre-Transplant

5 cm long bone gap
3 previous treatment failures
Limited weight bearing ability
Constant pain

12 Months Post Transplant

Complete healing and gap closure
No pain
Normal function & weight bearing
No adverse events

Full load-bearing capacity 2.5 months after BonoFill™ transplantation

13 months post transplantation, the patient took part in the Iron Man competition

When Danny Yaakobson, an extreme sports enthusiast, suffered a serious leg injury following a car accident, he did not imagine he would become the world’s first patient to receive Bonus BioGroup’s lab-grown bone implant, made from his own fat cells, to replace a missing section of his shinbone, let alone take part in the ISRAMAN triathlon just a year following the surgery (as seen in the previous slide). The article on the left, was published in Ynet News, on 28.01.2019