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A personalized, viable bone graft

BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.

What makes BonoFill™ so unique?

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Broad applicability to all indications and bone gap sizes

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Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

Maxillofacial Bone Regeneration

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Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.

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Broad applicability to all indications and bone gap sizes

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Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

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Maxillofacial Bone Regeneration

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Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.

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Pre transplant, the patient’s average residual bone height was 6.6 mm

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3 months following BonoFillTM transplantation, average bone height was 14.8 mm

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6 months following BonoFillTM transplantation, bone height 15.8 mm, demonstrating new bone growth of 9.2 mm

BonoFillTM – Orthopedic Indication

Critical Bone Defect, Preliminary Results - BNS05

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 Pre-Transplant

  • 5 cm long bone gap
  • Three previous treatment failures
  • Limited weight bearing ability
  • Constant pain

12 Months Post Transplant

  • 5 cm long bone gap
  • Three previous treatment failures
  • Limited weight bearing ability
  • Constant pain

Full load-bearing capacity 2.5 months after BonoFill™ transplantation

 

 

BonoFillTM – Orthopedic Indication

Critical Bone Defect, Preliminary Results - BNS05

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 Pre-Transplant

  • 5 cm long bone gap
  • Three previous treatment failures
  • Limited weight bearing ability
  • Constant pain

12 Months Post Transplant

  • 5 cm long bone gap
  • Three previous treatment failures
  • Limited weight bearing ability
  • Constant pain

Full load-bearing capacity 2.5 months after BonoFill™ transplantation

 

 

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13 months post transplantation, the patient took part in the Iron Man competition

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When Danny Yaakobson, an extreme sports enthusiast, suffered a serious leg injury following a car accident, he did not imagine he would become the world’s first patient to receive Bonus BioGroup’s lab-grown bone implant, made from his own fat cells, to replace a missing section of his shinbone, let alone take part in the ISRAMAN triathlon just a year following the surgery (as seen in the previous slide). The article on the left, was published in Ynet News, on 28.01.2019

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INFORMATION FOR INVESTORS

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RESEARCH COLLABORATIONS & BUSINESS DEVELOPMENT INQUIRIES

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