Tissue engineering

Leveraging advancements in tissue engineering and regenerative medicine, Bonus Biogroup is developing investigational tissue-engineered solutions that integrate cells with biomaterials to support the repair and regeneration of hard and soft tissues.

Organs and tissues injured or damaged by trauma or disease are hard to replace.

Vast tissue and organ damage are not infrequent. When bone or muscle tissues are critically injured and cannot heal by themselves, the only solution remaining requires, sometimes, harvesting tissues from another part in the patient body and implanting it back. Such self or autologous transplantations often lead to grave morbidities, infections, and complications. In other cases, when tissues and organs are not redundant, organ donation remains the only option with considerable limitations of donor shortage and immune rejection.

It takes a village to grow a tissue

Tissue engineering seeks to overcome the limitations of self-transplants and organ donations by growing functional tissues outside the human body. In Bonus Biogroup, we developed and perfected means to sample cells from the patient using a minimally invasive process, professionalize these cells, and use them in conjugation with natural tissue scaffolds and specialized automated bioreactor systems to create personalized, viable, and functional human tissues.

Organs and tissues injured or damaged by trauma or disease are hard to replace

Severe injuries to bone and soft tissue may result in defects that cannot heal on their own, often requiring grafting procedures. Current treatment approaches include autologous grafts, which involve tissue transplantation from the patient’s own body but may be limited by donor site availability and complications. In other cases, when self-donor tissue is not an option, organ transplants are used but face challenges such as donor shortages and immune rejection.

It takes a village to grow a tissue

Tissue engineering aims to address the limitations of self-transplants and organ donations by enabling the growth of functional human tissues outside the body.

Bonus Biogroup’s platform technology integrates professionalized autologous mesenchymal cells with natural scaffolds to support tissue regeneration. Our proprietary bioreactor system is designed for automation and to optimize cell expansion and differentiation while maintaining stringent control over growth conditions to ensure consistency and quality.

BonoFill: Personalized Bone Regeneration

BonoFill is designed to address the limitations of existing bone regeneration and reconstruction therapies.

This investigational tissue-engineered bone graft combines autologous mesenchymal cells with a three-dimensional (3D) biocompatible and bioactive mineral scaffold and is cultivated using our proprietary bioreactor growth system. The result is a viable bone graft grown ex vivo (outside the human body), intended to be tailored to each patient’s unique biological, physical, and clinical needs.

BonoFill is currently being evaluated in clinical trials for maxillofacial, dental, and orthopedic applications to assess its safety and potential therapeutic use.

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Artificial Blood Vessels for Integrating Transplanted Lab-Grown Organs

One of the key challenges in tissue engineering is enabling lab-grown tissues to develop functional vascular networks. Without proper blood vessel integration, engineered tissues may face limitations in oxygen and nutrient delivery, potentially affecting graft viability after transplantation.

Bonus Biogroup is conducting preclinical research focused on cell-based technologies and scaffold materials designed to support vascularization in engineered tissues.

These investigational approaches aim to enhance tissue viability by promoting the formation of functional blood vessels, potentially supporting more effective graft integration. The concepts are currently being evaluated in preclinical models.