BONUS BIOGROUP (TASE: BONS) is a clinical-stage biotechnology company, engaged in research and development of biomedical tissue-engineered and cell therapy products.
Bonus BioGroup applies an innovative and proprietary technology for the manufacturing of BonoFill, a tissue-engineered, individualized, viable bone graft for bone tissue regeneration. The company strives to become a world leader in the field of bone tissue engineering for the treatment of various complex bone deficiencies.
COVID-19 Therapy: Bonus BioGroup has joined the global research efforts for a coronavirus therapy. MesenCure is a newly developed cell therapy, specifically designed to treat the life-threatening cytokine storm in COVID-19 pneumonia.
Clinical Trials
Covid-19 Therapy: Bonus BioGroup is conducting a phase I/II clinical trial for the evaluation of MesenCure's safety and efficacy in the treatment of respiratory distress in Covid-19 infection.
Bonus BioGroup has currently two ongoing phase I/II clinical trials for the evaluation of BonoFillTM bone graft’s safety and efficacy in the orthopedic and maxillofacial indications:
In August, 2017 Bonus announced the first transplantation of BonoFillTM viable, human bone graft, grown outside the patient's body, into a patient’s arm, as part of a clinical trial for reconstruction of extensive critical bone loss in the extremities.
Maxillofacial Bone Regeneration
Bonus BioGroup commenced a clinical trial to evaluate the safety and efficacy of BonoFillTM in the treatment of oral and maxillofacial bone deficiencies, in the indications of sinus augmentation and filling of bone voids.
Clinical Trial Patient Recruitment

News and Press Release
- MesenCure, combined with an oncological treatment, ameliorated a life-threatening syndrome Written on Wednesday, 27 April 2022 15:13
- The Company's transition to the new Bonus BioGroup Center, in MATAM Advanced Technologies Park, Haifa, has been completed Written on Tuesday, 29 March 2022 06:38
- Bonus BioGroup applied to the Israeli Ministry of Health for emergency use authorization of the drug MesenCure for severe Covid-19 patients and submitted results of phase II, multicenter, controlled clinical trial, demonstrating outstanding efficacy Written on Monday, 10 January 2022 07:47
- MesenCure treatment resulted in a survival rate of 94% of the severe patients treated and reduced their hospitalization period by about half Written on Wednesday, 24 November 2021 04:40
- A patent approval secures Bonus BioGroup protection for the exclusivity of use and commercialization in Europe, in addition to the US, of Engineered Nanoparticle Technology, which may enable the development of a variety of therapies for the accelerat Written on Sunday, 17 October 2021 04:24

Products
BonoFillTM Product Family
Bone grafts are required for bone deficiencies incapable of self-healing, which arise in numerous medical conditions, including trauma and bone diseases.
Bonus BioGroup has developed a novel procedure to grow an autologous, viable bone graft from cells derived from the patient's adipose (fat) tissue, obtained by a simple procedure of liposuction. BonoFillTM bone graft is an exclusive, 3D, high cell density bone graft designed to fit the defect site. The bone graft’s unique cell composition efficiently promotes new bone growth, the healing of the bone defect and the integration with the existing bone.
BonoFillTM bone graft is tailored to the biological, physical and clinical needs of each patient, especially with regard to treatment of complex bone defects.
Currently, BonoFillTM is being evaluated in phase I/II clinical trials for the repair of bone deficiencies in the orthopedic indication and in the maxillofacial indication.
MesenCure – COVID-19 Therapy
MesenCure is a cell-based therapy specifically developed to attenuate the hyper-inflammatory response in COVID-19 pneumonia and the alleviate the life-threatening respiratory distress. The mesenchymal stromal cells are isolated from the adipose tissue of healthy donors, expanded in the laboratory and are subjected to specific procedures which are designed to prime the cells and to enhance their immunomodulatory capabilities. Upon intravenous injection of MesenCure, the cells reach the lung where they attenuate the cytokine storm, alleviate the respiratory distress and promote the healing of the injured lung.
Currently, Bonus BioGroup is conducting a phase I/II clinical trial with MesenCure at the largest medical center in the north of Israel.
Science & Technology
Tissue-engineered bone graft:
Bonus BioGroup has developed an injectable bone graft, manufactured from the cells isolated from the patient’s adipose (fat) tissue. Why adipose tissue? Human adipose (fat) tissue has significant advantages as a cell source for tissue engineered products. Adipose tissue-derived mesenchymal stromal cells (ASCs) can be grown and differentiated into multiple cell lineages in the laboratory, including bone-forming cell (osteoblasts), which can be safely and efficiently transplanted back into the patient.
Bonus’ BonoFillTM bone graft has the advantage being an autologous product, made from the patient’s cells. The isolated mesenchymal cells are cultured in a bioreactor on a supportive natural mineral matrix (scaffold), and induced to generate BonoFill’s unique cell composition.
BonoFillTM is designed to fit the defect site, and optimally promotes the bone regenerations process from within the bone graft as well as by recruiting cells from the healthy surrounding tissue, without the risk of graft rejection.
COVID-19 cell-based immunomodulatory therapy:
Human adipose (fat) tissue-derived mesenchymal stromal cells (ASCs) are researched as COVID-19 therapy due to their immunomodulatory capabilities to attenuate the hyper-inflammatory response – the life-threatening cytokine storm triggered by the novel coronavirus.
Bonus BioGroup has developed a procedure to specifically prime the ASCs and to enhance the cells’ immunomodulatory potential, while maintaining their safety. In preclinical studies, Bonus’ COVID-19 therapy MesenCure was shown to attenuate the hyper-inflammatory response in the lungs, as well as to promote the healing of the injured lung tissue.
The ASCs are isolated from the adipose of healthy human donors and, in addition to their immunomodulatory capabilities, these cells are also immune-evasive, meaning that the undifferentiated mesenchymal stromal cells are not recognized by the immune system as foreign and do not elicit an immune response.