BonoFill™
A personalized, viable bone graft
BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.
BonoFill™
A personalized, viable bone graft
BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.
What makes BonoFill™ so unique?
- Minimal risk of graft rejection: Grown from cells obtained from the patient
- Tailor-made for optimal healing: Designed to precisely fit the patient anatomical deficiency
- Diversified cell culture to improve regeneration: Cells are in a spectrum of the differentiation to maximize bone regeneration
- 3D scaffold mimicking the natural bone composition: FDA- and EMA-approved mineral scaffold, safe and supports bone regeneration
- Proprietary bioreactor: Scalable and allows cost-effective production of safe and high-quality product
- Versatile applications: Accommodates a range of bone deficiencies - available upon demand and in large quantities
Broad applicability to all indications and bone gap sizes
Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.
Broad applicability to all indications and bone gap sizes
Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.
Maxillofacial Bone Regeneration
Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.
Pre transplant, the patient’s average residual bone height was 6.6 mm
Three months following BonoFillTM transplantation, average bone height was 14.8 mm
Six months following BonoFillTM transplantation, bone height 15.8 mm, demonstrating new bone growth of 9.2 mm
BonoFillTM – Orthopedic Indication
Critical Bone Defect, Preliminary Results - BNS05
Pre-Transplant
- 5 cm long bone gap
- Three previous treatment failures
- Limited weight bearing ability
- Constant pain
12 Months Post Transplant
- Complete healing and closure of the bone gap
- Normal function
- No pain
- No product-related AE’s were reported
Full load-bearing capacity 2.5 months after BonoFill™ transplantation
13 months post transplantation, the patient took part in the Iron Man competition
When Danny Yaakobson, an extreme sports enthusiast, suffered a serious leg injury following a car accident, he did not imagine he would become the world’s first patient to receive Bonus BioGroup’s lab-grown bone implant, made from his own fat cells, to replace a missing section of his shinbone, let alone take part in the ISRAMAN triathlon just a year following the surgery (as seen in the previous slide).
The article on the left, was published in Ynet News, on 28.01.2019
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