BonoFill™

bonus 1a

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A personalized, viable bone graft

BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.Path 42



BonoFill™

bonus 1a

Path 41

A personalized, viable bone graft

BonoFill is an injectable high-density culture of regenerative cells derived from the patient’s adipose tissue and grown on a biocompatible 3-dimensional mineral scaffold.Path 42



What makes BonoFill™ so unique?

  • Minimal risk of graft rejection: Grown from cells obtained from the patient
  • Tailor-made for optimal healing: Designed to precisely fit the patient anatomical deficiency
  • Diversified cell culture to improve regeneration: Cells are in a spectrum of the differentiation to maximize bone regeneration
  • 3D scaffold mimicking the natural bone composition: FDA- and EMA-approved mineral scaffold, safe and supports bone regeneration
  • Proprietary bioreactor: Scalable and allows cost-effective production of safe and high-quality product
  • Versatile applications: Accommodates a range of bone deficiencies - available upon demand and in large quantities
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Broad applicability to all indications and bone gap sizes

Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

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Broad applicability to all indications and bone gap sizes

Designed for bone reconstruction as a result of various bone diseases, applicable in variable sizes of damages.

Maxillofacial Bone Regeneration

Pre-transplant, all participants in our Phase II clinical trial for maxillofacial bone regeneration were diagnosed with a low-quality residual upper jawbone and insufficient bone height for dental implantation. However, within six months after BonoFill™, the patients’ bone height increased by an average of 9.2 mm, allowing the insertion of dental implants in 94% of the patients.

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Pre transplant, the patient’s average residual bone height was 6.6 mm

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Three months following BonoFillTM transplantation, average bone height was 14.8 mm

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Six months following BonoFillTM transplantation, bone height 15.8 mm, demonstrating new bone growth of 9.2 mm

BonoFillTM – Orthopedic Indication

Critical Bone Defect, Preliminary Results - BNS05

Pre-Transplant

Pre-Transplant
  • 5 cm long bone gap
  • Three previous treatment failures
  • Limited weight bearing ability
  • Constant pain

12 Months Post Transplant

12 Months Post Transplant
  • Complete healing and closure of the bone gap
  • Normal function
  • No pain
  • No product-related AE’s were reported

Full load-bearing capacity 2.5 months after BonoFill™ transplantation

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13 months post transplantation, the patient took part in the Iron Man competition

When Danny Yaakobson, an extreme sports enthusiast, suffered a serious leg injury following a car accident, he did not imagine he would become the world’s first patient to receive Bonus BioGroup’s lab-grown bone implant, made from his own fat cells, to replace a missing section of his shinbone, let alone take part in the ISRAMAN triathlon just a year following the surgery (as seen in the previous slide).

The article on the left, was published in Ynet News, on 28.01.2019

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