Clinical trials

Clinical Trials

Orthopedic Bone Regeneration

In August, 2017 Bonus announced the first human tissue-engineered bone graft transplantation, grown outside the patient's body and transplanted into a patient’s arm, as part of the phase I/IIa clinical trial for reconstruction of extensive critical bone loss in the extremities.

rospective, single, open label, single arm, that evaluates the safety and efficacy of BonoFill-II in adult males and females (ages 18-80), as an adjunct to standard fixation methods for regeneration of large bone defects, incapable of self- healing, when bone healing by standard surgical techniques is either impractical and/or no medical solution exists, in the following medical conditions:

Long and short bones extra articular comminuted fracture,
Long and short bones extra and intra articular defect/gap or non- union, incapable of self-regeneration. Intra articular non-union is a result of unsuccessful –arthrodesis (artificial induction of joint ossification between two bones by surgery)

rospective, single, open label, single arm, that evaluates the safety and efficacy of BonoFill-II in adult males and females (ages 18-80), as an adjunct to standard fixation methods for regeneration of large bone defects, incapable of self- healing, when bone healing by standard surgical techniques is either impractical and/or no medical solution exists, in the following medical conditions:

Long and short bones extra articular comminuted fracture,
Long and short bones extra and intra articular defect/gap or non- union, incapable of self-regeneration. Intra articular non-union is a result of unsuccessful –arthrodesis (artificial induction of joint ossification between two bones by surgery)

Maxillofacial Bone Regeneration

This clinical trial is conducted in order to evaluate the safety and the efficacy of BonoFill^TM as bone filler for the reconstruction of oral and maxillofacial bone deficiencies in the two clinical indications:

Bone augmentation
Bone grafting for the purpose of void filling following removal of cysts from jaws

The study is a phase I/IIa, open label, clinical trial for the evaluation of the ability of BonoFill^TM to induce bone regeneration and to serve as a bone graft in the jaws.