Preclinical Study

BonoFillTM bone graft for the treatment of critical-sized bone defects

One of the major challenges in the field of bone regeneration is the treatment of critical-sized bone defects. Due to the large gap, the body is not able to heal itself, and current treatment options include mainly autologous bone grafting, which is a limited solution predominantly due to the limited volume of the bone graft available for harvesting. 

Bonus BioGroup demonstrated in preclinical studies in sheep critical-gap model the efficacy of BonoFillTM in the tissue regeneration of large-segmental bone gaps of 3.2 cm in the sheep tibia. The healing process was followed by X-ray imaging and close monitoring of the sheep’s well-being and health condition. The results demonstrated the successful closure of the gap within 8-12 weeks following BonoFillTM treatment, with no signs of graft rejection.


Ben-David, D., Fishman, B., Rubin, G. et al. Autologous cell-coated particles for the treatment of segmental bone defects—a new cell therapy approach. J Orthop Surg Res 14, 198 (2019).


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